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in San Diego, CA

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Hours Full-time, Part-time
Location San Diego, California 92103
San Diego, California

About this job

Seeking a highly motivated and experienced Sr. Associate Scientist. The successful candidate needs to have a strong background in molecular and cellular immune biology with experience in biologics drug discovery. The qualified candidate will participate in testing novel antibody candidates in functional assays in addition to performing mechanism-based in vitro studies. This candidate will implement existing HTS platforms to assess target binders for functionally in relevant systems to support multiple programs at varying stages of antibody discovery. Excellent communication and interpersonal skills demonstrated in a team environment are essential, as well as experience with software applications for storing, processing and presenting data.

Responsibilities will include, but are not limited to, the following:

  • Coordinate the testing of incoming biologics including bispecific antibodies for cellular target binding and related functional activity.
  • Based on directions from supervisor, design and execute complex human cell based assays and mechanism of action studies. Also, perform routine and complex data analysis to triage leads for affinity maturation.
  • Isolate and expand human primary immune cell populations for in vitro functional assays.
  • Perform routine Biotherapeutics assays on identified antibody leads prior to DC nomination, including FcR binding, effector function, and human cytokine release.
  • Cross-trained in multiple flow cytometry platforms. Also have the capacity to assist colleagues in performing flow analysis.
  • Routine presentations of experimental plans and data in team and department settings

Skills/Knowledge Required:

  • Solid understanding of cellular immunology
  • Familiar with multi-parameter flow cytometry analysis (surface/intracellular staining) using LifeTechnology Attune, BD Celesta FACsCalibur etc. Experience in High Content Imaging system a plus.
  • Proficiency with FlowJo, Prism, Microsoft office applications
  • Expert understanding in tissue culture, human and cynomolgus immune cell isolations, and familiarity with gene reporter systems
  • Familiarity in molecular and biochemistry techniques, including cell transfections, Western blotting, DNA manipulations, and qPCR analysis, are desired.
  • Fundamental knowledge and understanding of drug discovery and antibody discovery process is preferred.

PREREQUISITES

  • Bachelor's degree in a scientific discipline with at least 4 years of work experience.




About Aerotek:

Our people are everything. As a Best of Staffing® Client and Talent leader, Aerotek® Inc. has distinguished itself as a leader in recruiting and staffing services, by having a deep understanding of the intersection of talent and business. As a strategic partner to more than 17,000 clients and 300,000 contract employees every year, Aerotek's people-focused approach yields competitive advantages for its clients and rewarding careers for its contract employees. Headquartered in Hanover, Md., Aerotek operates a network of over 230 non-franchised offices with more than 6,000 internal employees dedicated to serving our customers. Aerotek is an operating company of Allegis Group, a global talent solutions provider. To learn more, visit .

Aerotek is acting as an Employment Agency in relation to this vacancy.